farnesylation, lamin, nuclear periphery, intermediary filament, senescence, microcephaly
5q23.3-q31.1
Homo sapiens
Interphase
nuclear periphery
nuclear lamina
583
586
farnesylation CaaX motif
GO:0007001
chromosome organization and biogenesis (sensu Eukaryota)
GO:0006997
nuclear organization and biogenesis
GO:0007052
mitotic spindle assembly
GO:0007420
brain development
GO:0090398
cellular senescence
required for mouse development and nuclear integrity