or browse by
compartment
or
motif
About
Links
Statistics
Web Services
FAQs
Names
X
Name
Species
Main
HDAC7
Homo sapiens, Mus musculus
True
HDAC7A
False
Keywords
+
Location
X
Location
Species
12q13.1
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nuclear-cytoplasmic shuttling
Serum withdrawal leads to the translocation of HDAC7 from the nucleus into the cytoplasm.
PubMed:11279209
PubMed:12753745
Interphase
nuclear
and in mitochondrial inner membrane space (IMS). Relocates to cytoplasm on initiation of apoptosis
PubMed:15364908
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
103
7.24
952
Entrez Protein:NP_056216
101.3
7.11
938
Entrez Protein:NP_062518
Uniprot:Q9JL72
Annotation
X
Start
End
Domain
Description
151
167
NLS BP
183
190
NLS
518
865
HDAC
class II
174
190
NLS BP
206
213
NLS
505
852
HDAC
class II
Biological Process
X
GO ID
Term
Links
GO:0006338
chromatin remodeling
PubMed:11279209
GO:0000122
negative regulation of transcription from Pol II promoter
PubMed:11279209
GO:0033233
regulation of protein sumoylation
pubmed:18625722
GO:0030578
PML body organization
pubmed:18625722
Molecular Function
X
GO ID
Term
Links
GO:0004407
histone deacetylase activity
PubMed:11467738
Other Function
X
Function
Links
muscle differentiation. Prevents MEF2 gene activation by binding. Sequestered to cytoplasm upon induction of differentiation.
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
HDA1
Saccharomyces cerevisiae
PubMed:11467738
History
+