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Names
X
Name
Species
Main
DNA topoisomerase II alpha
False
Top IIa
False
TOP2A
False
topoisomerase II alpha
Homo sapiens
True
Keywords
+
Location
X
Location
Species
17q21-q22
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
prophase - meiosis
heterochromatin
centromeric heterochromatin
PubMed:10654080
G2
centromere
centromeric heterochromatin concentration
PubMed:8794854
metaphase - mitosis
centromere
until mid anaphase
PubMed:12105179
PubMed:8794854
prometapha
chromosome core
PubMed:12105179
PubMed:15609038
PubMed:8653270
S - interphase
heterochromatin
in late S
PubMed:14978217
Interphase
splicing speckles
catalytically inactive form
PubMed:14978217
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
174.4
8.82
170
1531
Entrez Protein:P11388
PubMed:16100112
OMIM:126430
Entrez Protein:NP_001058
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006915
apoptosis
PubMed:10959840
GO:0007002
centromere binding
PubMed:11263492
GO:0007076
mitotic chromosome condensation
PubMed:8088460
GO:0000398
nuclear mRNA splicing, via spliceosome
PubMed:11991638
GO:0006350
transcription
PubMed:11574892
GO:0000070
mitotic sister chromatid segregation
PubMed:7559788
pubmed:17956945
GO:0070683
decatenation checkpoint
pubmed:19098900
pubmed:20562910
GO:0071932
replication fork reversal
pubmed:33296677
Molecular Function
X
GO ID
Term
Links
GO:0004002
ATPase activity
PubMed:16100112
OMIM:126430
PubMed:9836594
GO:0003918
DNA topoisomerase (ATP-hydrolyzing) activity
OMIM:126430
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Immunohistochemistry
proliferating cells
PubMed:11170002
Related Genes
X
Name
Species
Links
DNA topoisomerase II alpha
Gallus gallus
PubMed:11453553
DNA topoisomerase II
Drosophila melanogaster
PubMed:11172718
DNA topoisomerase II
Schizosaccharomyces pombe
PubMed Central:9763441
History
X
Created On
Last Changed
2001-09-19 10:06:29
2004-12-02 15:09:52