Names
X
Name
Species
Main
DNA topoisomerase II alpha 
 
False 
Top IIa 
 
False 
TOP2A 
 
False 
topoisomerase II alpha 
Homo sapiens 
True 
Keywords
+
Location
X
Location
Species
17q21-q22 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
prophase - meiosis 
heterochromatin 
centromeric heterochromatin 
PubMed:10654080
G2 
centromere 
centromeric heterochromatin concentration 
PubMed:8794854
metaphase - mitosis 
centromere 
until mid anaphase 
PubMed:12105179
PubMed:8794854
prometapha 
chromosome core 
 
PubMed:12105179
PubMed:15609038
PubMed:8653270
S - interphase 
heterochromatin 
in late S 
PubMed:14978217
Interphase 
splicing speckles 
catalytically inactive form 
PubMed:14978217
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
174.4 
8.82 
170 
 
1531 
Entrez Protein:P11388
PubMed:16100112
OMIM:126430
Entrez Protein:NP_001058
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006915 
apoptosis 
PubMed:10959840
GO:0007002 
centromere binding 
PubMed:11263492
GO:0007076 
mitotic chromosome condensation 
PubMed:8088460
GO:0000398 
nuclear mRNA splicing, via spliceosome 
PubMed:11991638
GO:0006350 
transcription 
PubMed:11574892
GO:0000070 
mitotic sister chromatid segregation 
PubMed:7559788
pubmed:17956945
GO:0070683 
decatenation checkpoint 
pubmed:19098900
pubmed:20562910
GO:0071932 
replication fork reversal 
pubmed:33296677
Molecular Function
X
GO ID
Term
Links
GO:0004002 
ATPase activity 
PubMed:16100112
OMIM:126430
PubMed:9836594
GO:0003918 
DNA topoisomerase (ATP-hydrolyzing) activity 
OMIM:126430
Other Function
X
Function
Links
Expression
+
Related Genes
X
Name
Species
Links
DNA topoisomerase II alpha 
Gallus gallus 
PubMed:11453553
DNA topoisomerase II 
Drosophila melanogaster 
PubMed:11172718
DNA topoisomerase II 
Schizosaccharomyces pombe 
PubMed Central:9763441
History
+