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Names
+
Keywords
+
Location
X
Location
Species
17q21-q22
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
prophase - meiosis
heterochromatin
centromeric heterochromatin
PubMed:10654080
G2
centromere
centromeric heterochromatin concentration
PubMed:8794854
metaphase - mitosis
centromere
until mid anaphase
PubMed:12105179
PubMed:8794854
prometapha
chromosome core
PubMed:12105179
PubMed:15609038
PubMed:8653270
S - interphase
heterochromatin
in late S
PubMed:14978217
Interphase
splicing speckles
catalytically inactive form
PubMed:14978217
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
174.4
8.82
170
1531
Entrez Protein:P11388
PubMed:16100112
OMIM:126430
Entrez Protein:NP_001058
Annotation
X
Start
End
Domain
Description
76
225
HATPase c
80
670
TOP2c
603
609
NLS
632
635
NLS
661
677
NLS BP
693
1169
TOP4c
727
743
NLS BP
1068
1071
NLS
1270
1291
NLS BP
1463
1468
NLS
Biological Process
X
GO ID
Term
Links
GO:0006915
apoptosis
PubMed:10959840
GO:0007002
centromere binding
PubMed:11263492
GO:0007076
mitotic chromosome condensation
PubMed:8088460
GO:0000398
nuclear mRNA splicing, via spliceosome
PubMed:11991638
GO:0006350
transcription
PubMed:11574892
GO:0000070
mitotic sister chromatid segregation
PubMed:7559788
pubmed:17956945
GO:0070683
decatenation checkpoint
pubmed:19098900
pubmed:20562910
GO:0071932
replication fork reversal
pubmed:33296677
Molecular Function
X
GO ID
Term
Links
GO:0004002
ATPase activity
PubMed:16100112
OMIM:126430
PubMed:9836594
GO:0003918
DNA topoisomerase (ATP-hydrolyzing) activity
OMIM:126430
Other Function
X
Function
Links
Expression
+
Related Genes
X
Name
Species
Links
DNA topoisomerase II alpha
Gallus gallus
PubMed:11453553
DNA topoisomerase II
Drosophila melanogaster
PubMed:11172718
DNA topoisomerase II
Schizosaccharomyces pombe
PubMed Central:9763441
History
X
Created On
Last Changed
2001-09-19 10:06:29
2004-12-02 15:09:52