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Names
X
Name
Species
Main
IK1
False
Ikaros
Gallus gallus, Homo sapiens, Mus musculus
True
LYF-1
False
ZNFN1A1
False
IKZF1
false
Keywords
X
acute lymphoblastic leukemia ALL, cancer, chromatin remodelling, leukaemia, Lymphoid restricted. But Ikaros is present in most hematopoietic cells, lymphoma, lymphoma_associated translocation, nurd, quiescence, swi_snf, transcription repression, zinc finger C2_H2
Location
X
Location
Species
7p12
Homo sapiens
11
Mus musculus
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
heterochromatin
in pre-B lymphocytes
PubMed:10970879
PubMed:9435248
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
57.5
6.12
519
Entrez Protein:Q13422
OMIM:603023
Uniprot:Q13422
PubMed:23233609
517
Uniprot:Q03267
518
Entrez Protein:O42410
Uniprot:O42410
Annotation
X
Start
End
Domain
Description
117
139
ZnF_C2H2
145
167
ZnF_C2H2
173
195
ZnF_C2H2
201
224
ZnF_C2H2
462
484
ZnF_C2H2
490
514
ZnF_C2H2
Biological Process
X
GO ID
Term
Links
GO:0006338
chromatin remodeling
PubMed:11003653
PubMed:11799125
GO:0000122
negative regulation of transcription from Pol II promoter
PubMed:11387214
PubMed:11459831
GO:0000074
regulation of cell cycle
PubMed:15713624
Molecular Function
X
GO ID
Term
Links
GO:0003677
DNA binding
PubMed:10970879
Other Function
X
Function
Links
Fusion of the Ikaros and BCL6 genes in t(3;7)(q27;p12) translocations in DLBL.
PubMed:10753856
Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells, but also their earliest defined progenitors. Also haemopoietic defects and dleayed globin switching
PubMed: 7923373
PubMed:11805317
mice that express only non-DNA-binding dominant-negative 'leukemogenic' Ikaros isoforms lacking critical N-terminal zinc fingers develop an aggressive form of lymphoblastic leukemia
PubMed:10945610
Expression
+
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2001-09-21 16:38:08
2005-08-22 14:59:40