acute lymphoblastic leukemia ALL, cancer, chromatin remodelling, leukaemia, Lymphoid restricted. But Ikaros is present in most hematopoietic cells, lymphoma, lymphoma_associated translocation, nurd, quiescence, swi_snf, transcription repression, zinc finger C2_H2
Interphase
heterochromatin
in pre-B lymphocytes
GO:0006338
chromatin remodeling
GO:0000122
negative regulation of transcription from Pol II promoter
GO:0000074
regulation of cell cycle
Fusion of the Ikaros and BCL6 genes in t(3;7)(q27;p12) translocations in DLBL.
Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells, but also their earliest defined progenitors. Also haemopoietic defects and dleayed globin switching
mice that express only non-DNA-binding dominant-negative 'leukemogenic' Ikaros isoforms lacking critical N-terminal zinc fingers develop an aggressive form of lymphoblastic leukemia
2001-09-21 16:38:08
2005-08-22 14:59:40