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Names
X
Name
Species
Main
MBD2
Homo sapiens, Mus musculus
True
NY-CO-41
False
Keywords
X
DNA methylation, histone deacetylase complex, neocentromere, nurd, repression complex, RGG, transcription repression, MBD domain
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
heterochromatin
PubMed:10947852
PubMed:9774669
Mitosis
pericentric heterochromatin
PubMed:14519686
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
43.3
10.06
411
Entrez Protein:NP_003918
OMIM:603547
43.5
10.06
414
Entrez Protein:NP_034903
Uniprot:Q9Z2E1
Annotation
X
Start
End
Domain
Description
55
95
glycine arginine-rich
147
220
MBD
182
186
NLS
150
223
MBD
185
191
NLS
Biological Process
X
GO ID
Term
Links
GO:0006338
chromatin remodeling
PubMed:11297506
PubMed:10471499
GO:0006346
methylation-dependent chromatin silencing
PubMed:10471499
GO:0000122
negative regulation of transcription from Pol II promoter
PubMed:10471499
PubMed:12150909
Molecular Function
X
GO ID
Term
Links
GO:0003677
DNA binding
PubMed:9774669
GO:0003723
RNA binding
PubMed:15342650
Other Function
X
Function
Links
-/- mice are viable and fertile. Maternal behavior of Mbd2-/- mice is however defective
PubMed:11274056
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
+