C/EBP alpha
Homo sapiens
True
CCAAT/enhancer binding protein alpha
False
AML, cell cycle, differentiation, heterodimer, homodimer, leucine zipper, transcription factor, tumour suppressor
GO:0008285
negative regulation of cell proliferation
GO:0000122
negative regulation of transcription from Pol II promoter
GO:0006357
regulation of transcription from Pol II promoter
GO:0003702
RNA polymerase II transcription factor activity
-/- mice do not store hepatic glycogen. Hepatocytes and adipocytes fail to accumulate lipid. Critical for the establishment and maintenance of energy homeostasis in neonates
Die shortly after birth. Severely disturbed liver architecture. Impaired accumulation of glycogen and lipids in the liver and adipose tissue. Hypoglycaemic. Role in terminal differentiation hepatocytes.