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Names
X
Name
Species
Main
ESET
Mus musculus
False
H3-K9-HMTase 4
False
KIAA0067
Homo sapiens
False
SETDB1
Homo sapiens, Mus musculus
True
KMT1E
false
Keywords
X
H3K9 methylation, chromatin remodelling, histone deacetylase complex, histone methylase, Sin3, proviral silencing, pluripotency, PML bodies, meiotic prophase, meiotic gene silencing
Location
X
Location
Species
1q21.2
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
PML/ND10 bodies
pubmed:19811652
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
143.2
5.74
1291
Entrez Protein:NP_036564
OMIM:604396
Uniprot:Q15047
144.5
5.71
180
1307
Entrez Protein:NP_061365
Uniprot:O88974
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006342
chromatin silencing
PubMed:12398767
PubMed:11959841
pubmed:19884255
pubmed:20164836
pubmed:21427230
GO:0016571
histone methylation
PubMed:11791185
pubmed:19811652
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
pubmed:19884257
pubmed:19811652
GO:0019827
stem cell maintenance
pubmed:19884257
pubmed: 20014010
pubmed:19811652
GO:0007128
meiotic prophase I
pubmed:30393076
Molecular Function
X
GO ID
Term
Links
GO:0046974
histone lysine N-methyltransferase activity (H3-K9 specific)
PubMed:11791185
pubmed:19811652
Other Function
X
Function
Links
peri-implantation lethality between 3.5 and 5.5 dpc. No Eset(-/-) ES cell lines
PubMed:14993285
Expression
X
Experiment
Detail
Links
Northern
ubiquitous
In situ
zygotic Eset expression begins at the blastocyst stage and is ubiquitous during postimplantation mouse development
PubMed:14993285
Related Genes
X
Name
Species
Links
YNCA
Caenorhabditis elegans
Su(var)3-9
Drosophila melanogaster
History
X
Created On
Last Changed
2002-01-17 12:45:31
2005-08-18 13:20:20