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Names
X
Name
Species
Main
SIR2 ALPHA SIRTUIN TYPE 1
False
SIR2L1
False
SIRT1
Homo sapiens
True
sirtuin 1
False
SIRTUIN TYPE 1
False
Keywords
+
Location
X
Location
Species
10q22.2
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
PML/ND10 bodies
together with p53, when PML is overexpressed
PubMed:12006491
Interphase
nuclear-cytoplasmic shuttling
PubMed:17197703
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
81.7
4.55
747
Entrez Protein:NP_036370
OMIM:604479
Uniprot:Q9Y6F0
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006338
chromatin remodeling
PubMed:11672523
PubMed:15469825
GO:0000122
negative regulation of transcription from Pol II promoter
PubMed:12535671
GO:0006357
regulation of transcription from Pol II promoter
PubMed:14976264
PubMed:15220471
GO:0031507
heterochromatin formation
pubmed:18004385
pubmed:21504832
GO:0051567
histone H3-K9 methylation
pubmed:18004385
Molecular Function
X
GO ID
Term
Links
GO:0017136
NAD-dependent histone deacetylase activity
PubMed:11672523
PubMed:15469825
Other Function
X
Function
Links
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
PubMed:12960381
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
sir2
Saccharomyces cerevisiae
History
X
Created On
Last Changed
2002-05-28 12:24:34
2007-09-19 14:54:35