Class III HDAC, heterochromatin, deacetylase complex, histone deacetylase complex, PML bodies, transcription repression, H3K9 methylation
Interphase
PML/ND10 bodies
together with p53, when PML is overexpressed
Interphase
nuclear-cytoplasmic shuttling
GO:0006338
chromatin remodeling
GO:0000122
negative regulation of transcription from Pol II promoter
GO:0006357
regulation of transcription from Pol II promoter
GO:0031507
heterochromatin formation
GO:0051567
histone H3-K9 methylation
GO:0017136
NAD-dependent histone deacetylase activity
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.
sir2
Saccharomyces cerevisiae