Names
X
Name
Species
Main
SIR2 ALPHA SIRTUIN TYPE 1 
 
False 
SIR2L1 
 
False 
SIRT1 
Homo sapiens 
True 
sirtuin 1 
 
False 
SIRTUIN TYPE 1 
 
False 
Keywords
+
Location
X
Location
Species
10q22.2 
Homo sapiens 
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
PML/ND10 bodies 
together with p53, when PML is overexpressed 
PubMed:12006491
Interphase 
nuclear-cytoplasmic shuttling 
 
PubMed:17197703
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
81.7 
4.55 
 
 
747 
Entrez Protein:NP_036370
OMIM:604479
Uniprot:Q9Y6F0
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0006338 
chromatin remodeling 
PubMed:11672523
PubMed:15469825
GO:0000122 
negative regulation of transcription from Pol II promoter 
PubMed:12535671
GO:0006357 
regulation of transcription from Pol II promoter 
PubMed:14976264
PubMed:15220471
GO:0031507 
heterochromatin formation 
pubmed:18004385
pubmed:21504832
GO:0051567 
histone H3-K9 methylation 
pubmed:18004385
Molecular Function
X
GO ID
Term
Links
GO:0017136 
NAD-dependent histone deacetylase activity 
PubMed:11672523
PubMed:15469825
Other Function
X
Function
Links
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. 
PubMed:12960381
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
sir2 
Saccharomyces cerevisiae 
History
X
Created On
Last Changed
2002-05-28 12:24:34 
2007-09-19 14:54:35