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Names
X
Name
Species
Main
LIVER X RECEPTOR ALPHA
False
LXR-ALPHA
Homo sapiens, Mus musculus, Rattus norvegicus
True
LXRA
False
NR1H3
False
Keywords
X
nuclear receptor, heterodimer, ligand binding domain holi, zinc finger C4
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
50.5
7.96
447
Entrez Protein:Q13133
OMIM:602423
Uniprot:Q13133
445
Uniprot:Q9Z0Y9
445
Entrez Protein:Q62685
Uniprot:Q62685
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0050874
organismal physiological process
PubMed:17187055
GO:0006357
regulation of transcription from Pol II promoter
PubMed:9630215
Molecular Function
X
GO ID
Term
Links
GO:0003706
ligand-regulated transcription factor activity
PubMed:7744246
Other Function
X
Function
Links
Cholesterol and bile acid metabolism are impaired. k.o mice have no ability to respond normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in excess of that which they synthesize de novo
PubMed:9630215
Expression
X
Experiment
Detail
Links
Northern
strong expression of a 1.9-kb transcript in metabolic organs such as liver, kidney, and intestine
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2002-06-03 17:18:08
2007-07-27 12:26:03