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Names
X
Name
Species
Main
DOT1L
Homo sapiens, Mus musculus
True
DOTL
False
H3-K79-HMTase
False
KMT4
false
Keywords
X
histone methylase, heterochromatin, telomere, leukaemia, leukaemia_associated translocation, reprogramming, H3K79 methylation, dna damage response, transcriptional restart after DNA damage, ubiquitin binding, ubiquitinated histone binding
Location
X
Location
Species
19p13.3
Homo sapiens
Subcellular Localisation
X
Stage
Description
Details
Links
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
164.9
9.26
1537
Entrez Protein:NP_115871
PubMed:12628190
PubMed:15851025
OMIM:607375
Uniprot:Q8TEK3
PubMed: 21159644
1540
Entrez Protein:XP_125730
Annotation
X
Start
End
Domain
Description
395
417
NLS BP
422
428
NLS
1088
1091
NLS
1105
1111
NLS
1164
1170
NLS
Biological Process
X
GO ID
Term
Links
GO:0016571
histone methylation
PubMed:12123582
GO:0031151
histone methyltransferase activity (H3-K79 specific)
pubmed:18285465
pubmed:18787701
GO:0000723
telomere maintenance
pubmed:18787701
GO:0070829
heterochromatin maintenance
pubmed:18787701
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
pubmed:18285465
GO:0007067
mitosis
pubmed:19544450
GO:0048863
stem cell differentiation
pubmed:19544450
pubmed:22388813
GO:0034984
cellular response to DNA damage stimulus
pubmed:24809693
pubmed:23861670
pubmed:22373577
Molecular Function
X
GO ID
Term
Links
GO:0018024
histone-lysine N-methyltransferase activity
PubMed:12628190
GO:0031151
histone methyltransferase activity (H3-K79 specific)
pubmed:18285465
pubmed:12123582
pubmed:19544450
GO:0043130
ubiquitin binding
pubmed:22373577
GO:0061649
ubiquitinated histone binding
pubmed:22373577
Other Function
X
Function
Links
embryonic lethality E9.5
pubmed:18787701
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
Dot1
Saccharomyces cerevisiae
PubMed:12123582
History
+