Names
X
Name
Species
Main
DOT1L 
Homo sapiens, Mus musculus 
True 
DOTL 
 
False 
H3-K79-HMTase 
 
False 
KMT4 
 
false 
Keywords
+
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
164.9 
9.26 
 
 
1537 
Entrez Protein:NP_115871
PubMed:12628190
PubMed:15851025
OMIM:607375
Uniprot:Q8TEK3
PubMed: 21159644
 
 
 
 
1540 
Entrez Protein:XP_125730
Annotation
+
Biological Process
X
GO ID
Term
Links
GO:0016571 
histone methylation 
PubMed:12123582
GO:0031151 
histone methyltransferase activity (H3-K79 specific) 
pubmed:18285465
pubmed:18787701
GO:0000723 
telomere maintenance 
pubmed:18787701
GO:0070829 
heterochromatin maintenance 
pubmed:18787701
GO:0045944 
positive regulation of transcription from RNA polymerase II promoter 
pubmed:18285465
GO:0007067 
mitosis 
pubmed:19544450
GO:0048863 
stem cell differentiation 
pubmed:19544450
pubmed:22388813
GO:0034984 
cellular response to DNA damage stimulus 
pubmed:24809693
pubmed:23861670
pubmed:22373577
Molecular Function
X
GO ID
Term
Links
GO:0018024 
histone-lysine N-methyltransferase activity 
PubMed:12628190
GO:0031151 
histone methyltransferase activity (H3-K79 specific) 
pubmed:18285465
pubmed:12123582
pubmed:19544450
GO:0043130 
ubiquitin binding 
pubmed:22373577
GO:0061649 
ubiquitinated histone binding 
pubmed:22373577
Other Function
X
Function
Links
embryonic lethality E9.5 
pubmed:18787701
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
Dot1 
Saccharomyces cerevisiae 
PubMed:12123582
History
X
Created On
Last Changed
2003-02-28 09:22:01 
2005-01-21 13:49:31