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Names
X
Name
Species
Main
DYRK1A
Homo sapiens, Mus musculus, Rattus norvegicus
True
HP86
False
MNBH
False
Keywords
X
intellectual disability, CTD kinase, microcephaly, genetic disease, splicing speckles, serine threonine kinase, alternative splicing, wnt signalling, histone phosphorylation, autism
Location
X
Location
Species
21q22.1
Homo sapiens
16
Mus musculus
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
splicing speckles
PubMed:12799418
Interphase
nuclear and cytoplasmic
pubmed:25620562
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
85.6
8.9
763
Entrez Protein:Q13627
OMIM:600855
genelynxhs:ENSP00000318418
Uniprot:Q13627
PubMed:23099646
PubMed:25363760
763
Entrez Protein:Q61214
Uniprot:Q61214
763
Entrez Protein:Q63470
Uniprot:Q63470
Annotation
X
Start
End
Domain
Description
114
133
NLS BP
159
479
S_TKc
389
395
NLS
Biological Process
X
GO ID
Term
Links
GOIDHERE
alternative mRNA splicing, via spliceosome
pubmed:22767602
GO:0006468
protein phosphorylation
pubmed:22389395
pubmed:25620562
GO:0035412
regulation of catenin import into nucleus
pubmed:22389395
GO:0016572
histone phosphorylation
pubmed:24820035
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
pubmed:25620562
GO:0030217
T cell differentiation
pubmed:25998054
GO:0070816
phosphorylation of RNA polymerase II C-terminal domain
pubmed:29849146
Molecular Function
X
GO ID
Term
Links
GO:0004674
protein serine/threonine kinase activity
PubMed:12799418
pubmed:22389395
GO:0035173
histone kinase activity
pubmed:24820035
GO:0008353
RNA polymerase II carboxy-terminal domain kinase activity
pubmed:25620562
pubmed:29849146
Other Function
X
Function
Links
haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology
PubMed:12192061
Expression
X
Experiment
Detail
Links
Northern
ubiquitous
PubMed:8769099
specific neurons
pubmed: 23342120
Related Genes
X
Name
Species
Links
mnb
Drosophila melanogaster
PubMed:8769099
PubMed:22876196
History
+