Names
X
Name
Species
Main
IFI16 
Homo sapiens 
True 
IFNGIP1 
 
false 
PYHIN2 
 
false 
Keywords
X
innate immunity, DNA binding, nucleolus, transcription repression, p53 binding, senescence, senescence-associated secretory phenotype, pyrin, PAAD domain, HIN200, ob fold, viral restriction, brca1 complex, heterochromatin
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase 
nuclear 
 
pubmed:7536752
pubmed:14654789
Interphase 
nucleolus 
 
pubmed:754539
pubmed:14654789
Interphase 
nuclear & cytoplasmic 
translocates to cytoplasm upon activation 
pubmed:26121674
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
82.5 
 
 
 
729 
Entrez Protein:NP_001193496
pubmed:16678172
Annotation
X
Start
End
Domain
Description
6 
84 
PAAD_DAPIN 
 
145 
314 
HIN 
 
518 
685 
HIN 
 
Biological Process
X
GO ID
Term
Links
GO:0000122 
negative regulation of transcription from RNA polymerase II promoter 
pubmed:9642285
pubmed:25972554
GO:0045087 
innate immune response 
pubmed:23427152
pubmed:20890285
pubmed:24367117
pubmed:30193098
GO:0090398 
cellular senescence 
pubmed:12894224
pubmed:15208661
GOIDHERE 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 
pubmed:14654789
GO:0070869 
heterochromatin assembly involved in chromatin silencing 
pubmed:25972554
pubmed:30193098
Molecular Function
X
GO ID
Term
Links
GO:0003690 
double-stranded DNA binding 
pubmed:7536752
pubmed:754539
pubmed:22483801
pubmed:22618232
pubmed:24367117
pubmed:26673078
GO:0002039 
p53 binding 
pubmed:11146555
GO:0006330 
single-stranded DNA binding 
pubmed:18472023
GO:0003800 
antiviral response protein activity 
pubmed:22291595
pubmed:24154727
pubmed:25972554
GO:0061702 
inflammasome complex 
pubmed:26121674
GO:0043566 
structure-specific DNA binding 
pubmed:27280708
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
History
X
Created On
Last Changed
2013-08-01 14:03:41 
0000-00-00 00:00:00